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Kinase of the month

Kinase: Lyn kinase, FLJ26625, JTK8
Gene Links: iHOP
Biological significance: Key enzyme in the regulation of cell activation via Syk, PLCγ2 and PI3K


Competition:

Lyn kinase inhibitors Preclinical Melior Discovery WO2007024863 
Lyn kinase inhibitors Preclinical Childrens Medical Center/Yissum (Keryx?) WO2002047710 
Lyn knockout mice Preclinical Japan Science and Technology Corp (JST) WO0215680
Lyn knockout mice Preclinical Ludwig Inst US5859314, WO9714791 
INNO-406, Bcr-Abl/Lyn inhibitor Phase I, CML, ALL Nippon Shinyaku/Innovive  
Lyn B kinase inhibitor Preclinical, Cancer Onconova  
Lyn kinase peptide   US Gov US6084063
 
 
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(For the week ending July 18, 2008)

WO 2008/084103 AB Science Kinase (Unspec)
WO 2008/086269 Aerie Kinase (Unspec)
US20080171778 Array Bipharma MEK
US20080171734 AstraZeneca glucokinase
US20080171742 AstraZeneca IGF-1R
US7399780 AstraZeneca GSK3
US20080171755 Biogen Idec Alk5, Alk4
US20080171741 BMS p38
WO 2008/086128 BMS Kinase (Unspec)
US20080171747 Boehringer Ingelheim Kinase (Unspec)
WO 2008/086047 Boehringer Ingelheim RHO
US20080171769 Chembridge Multikinase
US20080171744 Critical Outcome Technologies Kinase (Unspec)
US20080171689 Five Prime FGFR
US20080171040 Genentech ErbB
US20080171718 Genta bcl2
WO 2008/086158 GSK PI3K
US20080171050 Imclone EGF
US20080171764 J&J mTOR
US7399764 Merck Akt
US20080171754 Millennium Raf
US20080171045 Oncomed DDR2
WO 2008/085191 Purdue Research Found HSP27
US7399612 Regeneron VEGF
US20080171710 Univ Rochester Fyn
US20080171874 Wyeth Kinase (Unspec)
US7399865 Wyeth Erbb2
Kinase.com
Protein Kinase Resource
 Protein Kinase Research Consortium
The Human Kinome
Receptor Tyrosine Kinase (RTK) Networks Consortium 

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  Upcoming Kinase Meetings

The Second q-bio Conference on Cellular Information Processing
August 6-9, 2008, Santa Fe, NM
Polo-like Kinases: From the Fly to the Clinic 20 Years Onwards
September 24 - 27, 2008, Porto, Portugal
Kinase Inhibitors
Oct 21-22 2008, Boston, MA
Targeting the PI3-Kinase Pathway in Cancer Prevention
Nov 11-14 2008, Cambridge, MA
Signaling Upstream of mTOR
November 3 - 5, 2008, Madrid, Spain

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Click here for a list of companies working on Kinase inhibitors

  
   

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